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This course focuses on the priciples of bioseparation processes: cellular fractionation, filtration, chromatography, electrophoresis, immunoaffinity techniques and their application to various types of biomolecules. It includes a hands-on laboratory to separate a target microbially-produced protein by chromatography and assay the purity by electrophoresis.
• Biomolecular properties (6 lectures)• Cellular fractionation and cell disruption techniques (5 lectures)• Liquid chromatography separations (7 lectures)• Electrophoresis (3 lectures)• Immunoaffinity methods (4 lectures)• Mammalian cell separations (3 lectures)• Final formulation (2 lectures)• Bioprocess case studies (5 lectures)
Having an overview of the separation and purification of biological materials.Understanding how to exploit biological molecular properties for their separation.Obtaining an overview of bioseparation principles to develop bioseparation strategies for complex biological mixtures.Understanding and applying the principles of process scale-up in bioseparation processes.Applying optimization and scale-up principles to design or improve a bioseparation process.
ENGR407
Students must attend one activity from each section.
36 lectures plus 2 labs. Students are expected to spend approximately 2 hours per week reviewing lecture content and preparing for labs, and an additional 10 hours per assignment.
Rachael Wood
Doran, Pauline; Bioprocess Engineering Principles ; 2nd; Elsevier, 2013.
Schuler, Michael, Kargi, Fikret and DeLisa, Matthew; Bioprocess Engineering: Basic Concepts ; 3rd; Prentice Hall, 2017.
Towler, Gavin and Sinnot, Ray; Chemical Engineering Design ; 3rd; Butterworth-Heinemann, 2022.
The recommended texts may be interesting/useful. There are no assigned textbooks for this course.
Domestic fee $1,268.00
International fee $6,238.00
* All fees are inclusive of NZ GST or any equivalent overseas tax, and do not include any programme level discount or additional course-related expenses.
For further information see Chemical and Process Engineering .