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The general principles of metabolism and metabolic control.
This course aims to communicate the fundamental principles governing the energy generating pathways within the cell. The major emphasis will be on carbohydrate metabolism and mitochondrial electron transport chain. Unlike BCHM221, this course will focus on biochemical systems and the functioning of their individual components.BCHM222 is a prerequisite for several courses in Biochemistry, Chemistry and Biology, particularly BCHM305, 306. Students wishing to major in biochemistry must pass BCHM202, BCHM212, BCHM222, BCHM281 and at least one of BCHM206 and BCHM253. Those who wish to learn more – including material at the frontiers of Biochemical Research – can continue in BCHM305, BCHM306, BCHM338, BCHM339.BCHM222 runs in semester two. It counts 15 points towards a Bachelor of Science degree and isrequired to major in biochemistry and preferably it is taken in conjunction with other 200-levelbiochemistry, biology and chemistry courses.
As a student in this course, I will develop the ability to: Apply concepts of enzymology to evaluate how the metabolism is coordinated (assessment task: final exam). Evaluate the importance of allosteric regulation for controlling metabolic flux (assessment task: final exam). Compare and contrast the different levels of metabolic regulation in a cell and between different types of cells (assessment task: final exam). Understand the molecular basis of metabolic diseases (assessment tasks: proposal assignment & final exam). Understand the molecular details of energy generation pathways and how they are integrated within metabolism (assessment task final exam). Synthesise primary scientific literature to provide necessary background and context for understanding and interpreting experimental data (assessment task: proposal assignment).Transferable Skills Register: Writing a research report. This will be important for any career in research or in an NGO, where you will need to write convincing applications for increasingly-limited funding. We will have tutorials to provide instruction on the elements of successful reports and help you identify these elements with clear marking rubrics. (Employable, innovative and enterprising) Synthesising information. In everyday life and in many job situations you will be required to read information from different sources, construct your own understanding and shape your own viewpoint. In lectures and tutorials, we will discuss recent research papers in a group environment and this will develop your abilities to identify the essential elements of research outputs - you will then use in proposal and report writing. (Employable, innovative and enterprising, Critically competent) Analysing data. Important for research, as well as in a number of private-sector organizations. This skill will be further developed when we assist you to analyse data we provide. (Employable, innovative and enterprising, Critically competent)
BCHM221 or BCHM253 or BIOL253
BCHM201, ENCH323
Students must attend one activity from each section.
Renwick Dobson
Steven Gieseg and Claudia Meisrimler
WEB-BASED RESOURCESVarious learning resources (lecture material, reference links, quizzes, discussion forums etc.) for thiscourse are available via the University of Canterbury’s Learn web site -- http://learn.canterbury.ac.nz/.This site will also be used regularly as a means of communication and information distribution for all ofyour Canterbury courses. You should familiarise yourself with Learn as soon as possible.TUTORIALS:These are workshops where the assignments work will be discussed and set. It will also be anopportunity to further discuss issues from the lectures and ask questions relating to the lecture material.Timing and location of the tutorials will be confirmed and communicated at lectures and on Learn.ASSIGNMENTS:This will take the form of written reports on topics set by the lecturers during the term. The topics will beon aspects of cell metabolism and designed to expand and test the student’s skills in scholarship-basedresearch. This will require reading and researching material introduced in lectures.WORKLOAD:Students should note that the Science Faculty recommends approximately 3.2 hours of additional studyfor each hour of lecture/workshop contact time at the 200-level.
Nelson, David L. , Lehninger, Albert L., Cox, Michael M; Lehninger principles of biochemistry ; 6th ed; W.H. Freeman, 2013.
If you buy an earlier edition (perhaps second hand – it’s cheaper), there is little difference between editions 4-6; however, when we refer to the text in lectures and tutorials we will always refer to page numbers in the 6th edition.OTHER USEFUL TEXTBOOKS:Garrett & Grisham "Biochemistry" (3, 4,) 5 Edition.The latest edition of “Biochemistry” by Lehninger is an alternative. Nelson and Cox Lehninger Principles of Biochemistry (5th edition) Voet and Voet Biochemistry (2nd edition)Hames and Hooper Instant Notes Biochemistry (2nd edition) Alberts et al., Molecular Biology of the Cell (4th edition) Buchanan et al., Biochemistry and Molecular Biology of Plants Horton et al Principles of BiochemistryZubay Biochemistry (4th edition) Stryer Biochemistry (4th edition)Mathews and van Holde Biochemistry (3rd edition) Lodish et al Molecular Cell Biology (3rd edition)Dobson, Gerrard and Pratt, Foundations of Chemical Biology, Oxford Chemistry Primer
Learn Site Course Outline
FEEDBACKCOURSE SURVEY 2020:Materials provided helped me to understand what was required. 3.78The organisation of this course helped me learn 3.81The overall workload in this course was 3.92I found the assessments appropriate for the course. 4.11I received helpful feedback on my progress 3.59Overall this was a good quality course 3.84Number of response for survey 70%COURSE SURVEY 2017:Materials provided helped me to understand what was required. 4.13The organisation of this course helped me learn 3.82The overall workload in this course was 3.77I found the assessments appropriate for the course. 3.96I received helpful feedback on my progress 3.58Overall this was a good quality course 3.85Number of response for survey 70%COURSE SURVEY 2015:This was a well organised course 3.8This course helped to stimulate my interest in the subject 4.2The overall workload in this course was 3.7Provided effective opportunities for active student participation was 4.2I received helpful feedback on my progress 3.5The assessments in this course measured my learning effectively 3.7Overall this was a good quality course 3.8Number of response for survey 14%
Domestic fee $1,036.00
International fee $5,188.00
* All fees are inclusive of NZ GST or any equivalent overseas tax, and do not include any programme level discount or additional course-related expenses.
For further information see School of Biological Sciences .